GENERAL BIOTECHNOLOGIES / SYS.BOOT
100
GB // SAN FRANCISCO · OXFORD
HUMAN ENHANCEMENT · LONGEVITY · FRONTIER TECHNOLOGIES
EST 2026 · 51.75°N 1.26°W
A programmable-biology company // XV · IV · MMXXVI

We
program

biology.

General Biotechnologies manufactures peptide therapeutics at a fraction of the current cost by genetically programming edible microbes to synthesise complex molecules.

LocationSF · OX
ManufacturingSacramento · Hyderabad
Next milestoneRegenesis™ 2028
ScrollExplore
University of Oxford
Horizon Europe · $4M
Featured in BBC · The Guardian · SynBioBeta
GB-01Manifesto

“Where do I think the next amazing revolution is going to come? For the very first time in our history, biology has the opportunity to be engineering, not science.”

// JENSEN HUANG — CEO, NVIDIA
Design compile Deploy living systems Design compile Deploy living systems
Flagship — GB-03

Regenesis

The world's first oral GLP-1 — made by, and delivered inside, an edible microbe. A single-dose daily powder. No cold chain. No needle. Peptides democratised.

Route20g · powder
Target price cap< US$ 5/dose
StageIn Development
Closes in 03:06:26:58
Our goals
0%
of the peptide protected from stomach acid and enzymes (lab-validated).
0mg
of peptide delivered per dose.
Real drugs.
Existing drugs. Remade in microbes. Not supplements.
0
peptide variants in pre-clinical testing — our own novel variants and already-approved GLP-1s.
Bay 01
GB-047
pH 8.2
28.4°C
LED 4,200 lx
OD₇₅₀ 1.42
CO₂ 0.3%
12h · 12h
January 2027 · Manufacturing Partnership

10,000 L Manufacturing Pilot — the first robotic cGMP-grade production of oral peptides.

Pilot · Sacramento Persist AI (YC 23)
GB-04 // Reformulation Platform/ 04

Peptides given a second life.

Deprioritised assets that are clinically proven but discontinued for business reasons, are given a second life as an oral drug.

01
01 / Origin

Discontinued peptides. Revived.

Pharma sits on libraries of peptide assets — clinically proven, discontinued for business reasons, not biology.

02
02 / Option Agreement

Sequence, optioned.

We request the rights to work with the shelved patented asset. In exchange the firm receives a right of first refusal to acquire or license the new oral product.

03
03 / Programme

Edible microbe makes the drug.

Our platform synthesises their drug molecule inside our programmable microbe.

04
04 / Produce

Identical peptide. Fraction of the cost.

The identical peptide, produced at high yield inside our programmable microbe — at a fraction of the cost.

05
05 / Prove

A new preclinical drug asset.

We conduct PK/PD animal studies to demonstrate that the drug successfully gets to the blood using our delivery approach. We also provide a report on the cost of making this drug as an oral formulation.

06
06 / License

Back to pharma.

A novel oral drug asset, returned to the pharma sponsor.

GB-05Biomanufacturing reimagined

Biomanufacturing reimagined: building the 3D printer for biology.

Portable. Light-powered.

Biology is all around us. From skin bacteria to plants that make thousands of bioactive compounds, the cell is the smallest unit performing sophisticated molecular transformation in the physical world. Genetic engineering gives us the command line for biology.

Our biomanufacturing manifesto
01 —

The story of biotechnology

Year marker 1993
2026 · present day
10,000 BC 01

Agriculture

Humanity's first biotechnology. Farming molecules from plants — limited to what they are naturally programmed to make.

3000 BC 02

Fermentation

5,000 years of fermentation added a layer of deliberate control — pairing specific yeasts with ingredients to transform one chemical into another.

1953 03

Discovery of DNA

Watson, Crick & Franklin reveal the blueprint — biology finally has a readable grammar.

1978 04

Genentech makes insulin from bacteria

Another layer of control: inserting genes into bacteria and yeast to brew drug molecules like insulin.

2012 05

CRISPR

Programmable molecular scissors. The genome becomes editable code — unlocking precision cures, climate-resilient crops, and designed living systems.

2020s 06

The era of programmable biology

AI tools, multi-omics datasets and computational biology accelerate drug discovery, protein engineering and strain engineering.

Drag · scroll · or use arrows 4 / 6
02 —

The roadmap to biomanufacturing abundance.

01 2030s →

Expansion in microbes

Programming thousands of cell lines from nature — not a handful — into fit-for-purpose manufacturing chassis. Starting with cyanobacteria.

02 2030s →

Bioreactors reimagined.

Bioreactors that can go anywhere and manufacture safely outside of a lab or cleanroom.

03 2030s →

Expansion in biochemistry

Expanding the sophisticated chemistry that a programmed cell can perform.

We invite FROs, startups and non-profits who are working on complementary technologies to collaborate with us.

Collaborate with us
GB-06Frontier Technologies

Coming soon.

Moonshot programmes at the frontier of human biology.

Global Health Defence Longevity Human Enhancement Global Health Defence Longevity Human Enhancement
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